How does your brain change with age? 

Duke Medical Center is looking for healthy adults 18-29 and 60-79 years of age.

With your participation, we can learn more about how attention, memory, and decision-making abilities are affected by aging.

Participants will be asked to participate in:

• 1 in-person session: clinic visit (1.5-2.5 hours)

Participants will be compensated for their time.

In collaboration with:

How does your brain change with age?

Duke Medical Center is looking for healthy adults 80-89 years of age.

With your participation, we can learn more about how attention, memory, and decision-making abilities are affected by aging, and how different regions of the brain contribute to these abilities!

Participants will be asked to participate in:

• Session 1: clinic visit (2-2.5 hours)
• Session 2 (if eligible): MRI visit (1.5-2 hours)

Participants will be compensated for their time.

In collaboration with:

Bridging Equity and Access in Care and Outcomes for DemeNtia (BEACON)

Are you, or someone you care for, living with dementia?

What is the BEACON Study?

Researchers want to learn what is most important to you and caregivers when getting healthcare. We want to better understand how to improve care for people living with dementia.

How does it work?

1. Fill out the contact information form
2. Complete a quick phone screening. We'll call you to ask a few more questions to see if you qualify.
3. Chat with our team on Zoom (or phone). If chosen to participate, we will schedule a time to talk for about 1 hour. We want to hear your thoughts and experiences about healthcare services.

Participants receive a $50 gift card for completing the conversation with a team member.

Examining the complex relationship between the emotional well-being of family caregivers and their care recipients with cognitive impairment

We are looking for volunteers to help us learn more about the complexity involved in the experiences and needs of family caregivers who provide care to those with cognitive impairment.

You may be eligible to participate if you:

• Are over 18 years old
• Are a family caregiver providing care to their loved one aged 65+ with a diagnosis of mild cognitive impairment or dementia

Participation includes one structured focus group workshop session that will take up to 4 hours and an optional follow-up interview that will take up to 1 hour.

Participants will be compensated $100 for their time.

Focus group sessions will be held in Chapel Hill, NC. Specific location is to be determined. Follow-up interviews will occur virtually.

The RepMem study is seeking adult, English-speaking participants for a study on how we think about objects. The goal of the study is to develop a better understanding of the effects of healthy aging on our representations for visual stimuli, and how this information might help contribute to the diagnosis of early AD and the development of memory training methods.

Participants will come into the lab at Duke’s Center for Cognitive Neuroscience for two separate testing sessions, and responses to visual stimuli will be tested in order to relate the brain images collected via functional magnetic resonance imaging (fMRI). The visual stimuli presented will be images of objects or scenes that many participants see in their daily life, or have general knowledge about (e.g. a penguin, an orange, a farm). Results from this project will advance our understanding of how age effects how we think about objects in daily living, and how object memories change across the lifespan. This research study is directed by Drs. Simon Davis and Roberto Cabeza, and is funded by the National Institutes on Aging.

You will be compensated for your study participation.

Duke University Center for Cognitive Neuroscience

The Effects of Aging on Word Prediction

Are you:

• Ages 18-35 or 65-85
• Native English speaker
• With no history of neurological or major psychiatric illness?

You may be eligible to participate in a research study on cognitive aging.

Participation involves:

• A 1-1.5 hour in-person visit to UNC-Chapel Hill
• Compensation of $15 per hour of participation
• Parking pass upon request

Can Brain Training Help Improve Mild Memory Loss?

Seeking volunteers with Mild Memory Loss for a new study.

Research Study Involves:

• Age 55-95 years
• Memory testing
• Brain MRI scans
• Computer Brain Training

Compensation for time and travel provided.

Preventing Alzheimer's with Cognitive Training (PACT) Study

We are seeking help for Preventing Alzheimer’s with Cognitive Training.

Every day, our dedicated team of researchers is working to find ways to prevent dementia, such as Alzheimer’s disease. We can’t do it alone. If you’re aged 65 and older, please volunteer for the PACT (Preventing Alzheimer’s with Cognitive Training) research study to see if computerized training exercises can reduce the risk of dementia.

Can You Help?

You may qualify if you:

• Are 65 years of age or older
• Do not have any neurological disorders
• Have not had a stroke or brain injury
• Do not have mild cognitive impairment or dementia such as Alzheimer’s disease

Potential Benefits of Computerized Training Exercises

Our research has shown that brain games may:

• Protect against dementia such as Alzheimer’s disease
• Enhance mental quickness and visual attention
• Improve gait speed and balance
• Improve driving safety
• Maintain health and well-being
• Allow you to perform everyday tasks more efficiently
• Protect against depression

Your Commitment

If you qualify, study participation takes about three years and includes 3 study visits of up to 2 hours each. You will also complete 45 one-hour computer training sessions on your own, in your own home.

IGROOVE: A Dance and Music Study for Older Adults with Memory Concerns

By joining the IGROOVE study, you can have fun and learn something new while helping to create knowledge about whether participating in the arts can improve heart and brain health. You’ll have the opportunity to meet new people, learn new things, and be social, all while contributing to the future of aging care and research.

Did you know physical activity, being social, and cognitive challenges are all important for brain health as you get older?

You may qualify to participate if you:

• Are 65 years old or older
• Have concerns about your memory, but no diagnosis of memory loss
• Would like to be more physically active
• Can commit to attend classes for up to three hours a week for six months
• Enjoy movement and music

You will learn about music and movement from experts in our community and you will be compensated for your time.

In collaboration with:

Time-Restricted Eating for Metabolic and Psychological Optimization (TEMPO)

Improve your brain and body health!

UNC TEMPO Research Trial

TEMPO stands for Time restricted Eating for Metabolic and Psychologic Optimization.

In this trial, we will study the effects of time-restricted eating times on mild cognitive impairment. Over 12 weeks, we will assess your memory and brain function, help you work on fasting with weekly trainings, and measure blood values via lab tests four times.

Who can join?

• 60 – 85 years old
• BMI over 30
• Changes in memory
• Sedentary

Benefits

Receive $200 for completing the study for the full 12 weeks.

Emotion and Physiology in Context (EPIC) Study

Do you want to learn more about your emotions? If you are aged 61+, you may be able to take part in a research study to explore how your brain and body create emotions.

The main purpose of The Emotion and Physiology in Context (EPIC) study is to better understand how brain function, physiology, and cognitive associations affect emotional experiences across the lifespan.

Who are we looking for?

People aged 61+ who want to participate in a brain imaging and physiology study.

What do you have to do?

• Virtual Session (~1 hour, Zoom): Participants will be asked to do cognitive tasks and complete surveys.
• Online survey (30 min; Virtual): Participants will be sent a link to do a survey at home.
• In-Lab Session (~2 hours; in-person): This session will take place at our lab space on UNC Chapel Hill's campus. Participants will be asked to complete a behavioral task, surveys and wear non-invasive physiological sensors on their body (i.e. ECG sensors).
• Remote Daily Surveys (~1hr per day; virtual): Participants will complete several surveys a day for 7 days.
• Scan Session (3 hours; in person: This session will take place at the UNC Chapel Hill Biomedical Research Participants will be asked to wear non-invasive physiological sensors on their body (i.e. ECG sensors) and complete an MRI scan.

During each session, participants will be answering questions about their physical and mental health, life experiences, emotions and cognitive associations. During the MRI scan, participants will be rating pictures. Some of the pictures may be upsetting. These pictures have been used in previous research studies; however, anyone with a severe phobia (i.e., extreme and uncontrollable fear of blood, spiders, snakes, corpses, weapons, and death) should consider not participating.

You will be compensated for your study participation.

University of North Carolina at Chapel Hill

Can Amazon Alexa Help Detect Memory Decline?

A research study to learn if voice recognition technology can help in the early detection of memory problems.

If you are 65 or older, you may be able to participate!*
*Internet access needed to participate virtually

• 2 hour study visit
• Compensation provided for time and travel

University of North Carolina at Chapel Hill

EXPosome in RobEson and Surrounding Counties: a Study of Brain Health (EXPRESS)

We are studying the microorganisms that live in your intestines and how they impact your brain health. We will ask that you provide a stool sample.

Are you 55 years or older?
Join our study and receive:

• Diet & cognitive screening
• Cholesterol & glucose test
• Blood pressure results
• Future blood tests

In collaboration with:

Experience, Advise, and Improve Brain Health Research

Join us to help improve the Add Health Parent Study!

We are looking for: 

• Adults ages 65 and older
• People who speak English and/or Spanish
• Residents of the Research Triangle Park area

Your participation will:

• Help to improve health research with a one-time interview
• Contribute to an important study about healthy aging
• Help to inform health outcomes related to aging

What should I expect during my interview?

• Share your life experiences by answering questions about health and aging
• Complete tasks related to your health and brain
• Provide small blood and saliva samples
• Give your feedback about the interview
• Participate for about 2 hours and 15 minutes
• Receive $150 compensation in cash for completing the interview

                          UNC Carolina Population Center

Infection and Inflammation in Mild Cognitive Impairment (MCI)

The purpose of this research study is to investigate the potential role of neuroinflammation in mild cognitive impairment (MCI).

Who is eligible?

• Ages 50-80
• Current diagnosis of mild cognitive impairment (MCI)

What will you receive?

• Up to $30
• Convenient parking at study site

What will be asked of you?

Participation involves one in-person visit to our clinic in Chapel Hill. You will be asked to complete several questionnaires, a brief cognitive test, and a single blood draw. The session typically takes about 45 minutes - 1 hour to complete. This study is purely observational and no treatment is involved.

University of North Carolina at Chapel Hill

Effect of a Ketogenic Diet on Alzheimer’s Disease Biomarkers and Symptoms: Brain Energy for Amyloid Transformation in AD Study (BEAT-AD)

Can a healthy diet improve memory?

We need your help to stop memory loss in older adults.

The BEAT-AD study is a 9-month study testing two different diets that may improve memory function and brain health in older adults who are experiencing mild memory problems.

The two study diets being compared are:
Mediterranean-style low-carb (ketogenic) diet or American Heart Association low saturated fat diet.

Who is eligible for BEAT-AD?
You may be eligible to participate in the study if you are:

• 55 – 85 years old
• Currently experiencing mild memory problems but do not have dementia or Alzheimer’s disease
• In good general health, and not taking medications for diabetes

What is involved when participating in BEAT-AD?

• Eligible volunteers will be placed in one of two groups at random, like flipping a coin
• One group will follow an American Heart Association low-fat diet for 4 months
• One group will follow a Mediterranean-style low-carb diet for 4 months
• Both groups will receive individual counseling with the study dietician, daily menus, and shopping lists
• Participants receive a physical exam, memory testing, and blood tests to check cholesterol, blood sugar, and general health both before, during, and after the study. A clinician will review your results with you at the end of the study, and give you personalized dietary recommendations
• Participants will receive a lumbar puncture (a common medical procedure) to collect a small amount of fluid twice during the study to help us understand how the diets affect important chemicals that are related to brain health
• Participants will receive brain scans twice during the study that will help us understand how the diets affect the brain
• You will be compensated for your study participation

Aging is the major risk for neurological (brain) disorders; delirium (confusion) is the most common complication in older adults following surgery, yet we do not know how to prevent it. Patients with pre-existing neurodegeneration (brain decline) are at even higher risk of developing postoperative complications after surgery. The proposed research will investigate the contribution of the gut microbiota (bacteria) to this serious public health concern.

You may be eligible for this research study if you:

• Are 60 years old or older
• Have NOT taken antibiotics over the last six months or over-the-counter probiotics capsules over the last month

Summary of Participation:

• The study consists of a 3-page survey about your diet
• Collect and submit a single fecal (stool) sample

Nature of the Study

• This study seeks to understand how gut bacteria contribute to confusion. We are particularly interested in knowing if this bacteria in children protects from disorders that cause the brain to decline as people get older.
• Participation is entirely voluntary. Participants will receive compensation after completion of the survey and fecal sample collection.
• The study will include testing your fecal (stool) bacteria.
• Your results will be provided to you upon your request.

Mindful coping and communication skills may be helpful to those under high stress and may improve health, the care you provide, and communication within the family. You can participate in 8 weekly phone calls that will focus on mindfulness skills and caregiving resources as a way to reduce stress and help family communication.

Who is eligible for this research study?

• Family caregivers who:
  • Are at least 18 years old
  • Provide regular care to a family member who:
    • is African American or Black
    • is living with Alzheimer’s disease or dementia
    • lives in Eastern NC
  • Have another family member who can join in the weekly phone calls

What is involved?

• Two visits with study staff (in-person or over the phone)
• 8 weekly, 1-hour, telephone sessions with other family caregivers and a trained instructor
• One Saturday retreat (in-person or over the phone)

If you participate in this research study, you will:

• Learn stress management and communication skills
• Receive a Caregiving Resource Guide
• Receive up to $100 for participating in study surveys

An fMRI study clarifying how individuals encode specific types of associative memories

Join a study in Duke Neurology where researchers are learning how healthy aging affects memory. This information might help contribute to the diagnosis of early Alzheimer’s Disease and the development of memory training methods.

We are looking for participants who are:

• English speaking
• Between the ages of 18-30 or 60-85 years old
• Don’t have a history of psychiatric or neurological illness

If you meet these criteria, we will ask you to come to Duke for one 3-hour session where you’ll look at pictures while getting a noninvasive and painless brain scan called functional magnetic resonance imaging (fMRI). You will also complete some cognitive tests. Participants will be compensated for their study participation.

Help us find out how the brain changes as we age!

Duke Medical Center is looking for healthy men and women ages 20-79

If you choose to be in this study you will:

• Complete one clinic visit (1.5-2 hours)
• Complete one MRI visit (2-2.5 hours, with 1.5-2 hours in the MRI scanner)

Brain Imaging and Analysis Center (BIAC)
Duke University and University of North Carolina at Chapel Hill

Plant-Based Supplement and Memory Study

What is the goal of ACE?
The main purpose of ACE is to determine if taking Equol, a plant based supplement, could slow the progression of stiffening of the arteries, small blood vessel disease in the brain and memory decline.

Who is able to participate in this study?

ACE is open to African American or Caucasian men and women, aged 65 to 85 years old who meet the eligibility criteria.

You may qualify to participate if you:

1. Are between the ages of 65-85
2. Do not have dementia
3. Are willing to have an MRI scan
4. Are willing to take the study supplement/placebo

What is involved to participate?
We will ask you to complete 7 clinic visits over a two year period so that we can evaluate any changes. Clinic procedures will include:

• Magnetic Resonance Imaging (MRI) of the brain
• Carotid Ultrasound of the arteries in the neck
• We will ask you to take soy tablets daily for 24 month

You will receive results of some assessments, will be compensated for your time and,
if needed, transportation can be provided at no cost.

In collaboration with:

Are you the primary caregiver of an individual recently diagnosed with a memory problem?

You may be eligible to participate in a study about barriers to diagnosis of memory problems

Who can participate?

• Primary caregivers of an individual diagnosed with a memory problem, such as dementia or Alzheimer’s Disease, in the past 24 months
• Black or African American, White, Hispanic/Latinx individuals

What would you do as part of the study?

• Complete a 60 to 90 minute interview in person, via Zoom or over the phone

Using Technology for Health Promotion in Older Adults with Cognitive Impairment

This is a UNC-CH research study (#22-0742) whose purpose is to obtain perspectives from older adults with early-stage Alzheimer’s Disease and related dementias and their caregivers’ on the use of telemedicine and how it relates to diet and exercise to slow cognitive decline.

Who can participate?
English speaking adults ages 65 or older who have been diagnosed with early-stage Alzheimer’s Disease and Related Dementias (ADRD) and their caregiver. Participants must also have internet service at home.

Time or other commitments required of participants:
Eligible participants will have a one-time 45–60-minute video-based Zoom or in-person session that includes an audio recorded interview and where they will also answer some additional questions. A $25 Amazon gift card is provided.

University of North Carolina at Chapel Hill